The short version: Adentris and Brellium are both AI chart-audit platforms for behavioral health, and they are close on the core idea: review clinical documentation against payer and regulatory requirements instead of sampling a few charts by hand. The differences that matter are timing and depth. Adentris reviews notes in real time before the claim is submitted and is built around SUD-specific rules like ASAM level of care and 42 CFR Part 2, and it runs on any EHR through a secure web agent. If you run a substance use disorder or behavioral health program, that is usually the deciding factor.
Both tools do the same fundamental job, so a head-to-head comes down to when the review happens, which rules it understands, how it connects to your EHR, and whether denials are handled in the same place. Here is an honest comparison.
What Adentris does
Adentris is an AI platform for revenue integrity and documentation compliance built specifically for behavioral health and SUD programs. It works on top of the EHR you already run, connecting through an API or HL7 where one exists (for example Alleva, Pimsy, Kipu, Epic, or Athenahealth) and through a secure web agent where it does not, so there is no migration. It reviews notes in real time and flags the elements that get behavioral health claims denied before the claim is submitted: medical necessity, ASAM level-of-care justification, treatment plan updates, group therapy attendance, service units, signature timing, and 42 CFR Part 2 consent. When something is missing, it drafts the correction for the clinician to accept, and it pairs documentation review with an appeals and denials module. Adentris is HIPAA compliant and SOC 2 certified, with 42 CFR Part 2 controls and BAAs in place.
What Brellium does
Brellium is an AI-powered clinical compliance and chart auditing platform with dedicated products for behavioral health, mental health, and ABA. It reviews clinical documentation against payer, regulatory, and quality requirements at scale, aiming to audit every chart rather than a sample, and it flags issues such as notes that lack individualized detail or lean on templated language, coding alignment, and treatment plans that have not been updated within required timeframes. It is well funded and used by a range of behavioral health and therapy organizations. For programs whose priority is broad clinical-quality auditing across behavioral health and ABA, Brellium is a strong option.
Adentris vs Brellium at a glance
| Adentris | Brellium | |
|---|---|---|
| Best for | BH and SUD programs focused on denials and compliance | Behavioral health, mental health, and ABA organizations |
| Primary job | Catch and fix denial-driving gaps before the claim is submitted | AI chart auditing against payer, regulatory, and quality standards |
| Review timing | Real time, before the claim is submitted | Automated chart auditing at scale, after documentation |
| Is it a scribe? | No, it reviews the note, however it was written | No, it audits charts, however they were written |
| SUD depth | ASAM level of care and 42 CFR Part 2 built in | Behavioral health, mental health, and ABA focus |
| EHR fit | Any EHR via API, HL7, or a secure web agent (no migration) | EHR integrations |
| Compliance focus | Payer claim denials and revenue integrity | Clinical-quality and payer or regulatory auditing |
| Denials | Paired appeals and denials module | Auditing and compliance focus |
Capabilities change quickly in this market, so confirm current details with each vendor before you decide.
Which should you choose?
Because both audit behavioral health charts against compliance rules, the real question is emphasis. Brellium is built around broad clinical-quality auditing across behavioral health, mental health, and ABA, reviewing charts at scale so problems surface for the team to work. Adentris is built around catching the specific gaps that get behavioral health and SUD claims denied and fixing them before submission: it flags a missing medical necessity statement, an ASAM level of care that was never justified, or a 42 CFR Part 2 consent that was not captured, and drafts the correction while the note is still open. For a SUD program in particular, the depth on ASAM and Part 2, the real-time pre-submission timing, and the ability to run on any EHR through a secure web agent are the practical differences.
- Choose Brellium if your priority is broad, at-scale clinical-quality auditing across behavioral health, mental health, and ABA, with issues surfaced in a report for your team to work through.
- Choose Adentris if you run a SUD or behavioral health program and the pain is denied claims: you want denial-driving gaps like ASAM level of care, medical necessity, and 42 CFR Part 2 consent caught and corrected before submission, with a paired appeals and denials module, on any EHR.
Adentris as a Brellium alternative for SUD and behavioral health
If your program uses Brellium, or is evaluating it, the question is usually whether you want auditing that reviews charts at scale or a layer that catches and corrects the gaps before the claim goes out, with SUD-specific rules built in. Many substance use disorder programs want the latter, because the claims they lose turn on ASAM level of care, medical necessity, and 42 CFR Part 2 consent, and they want the fix drafted in the moment rather than surfaced in a report. Adentris is built around exactly that, runs on any EHR through an API, HL7, or a secure web agent, and pairs the review with an appeals and denials workflow, which makes it a natural behavioral-health and SUD alternative. It can run alongside a broader auditing tool or in place of it.
How Adentris helps
For behavioral health and SUD organizations, the biggest revenue leak is documentation, and it is specific: medical necessity that was never shown, missing ASAM justification, a Part 2 consent that was not captured. Adentris reviews every chart in real time inside your existing EHR and flags exactly those gaps before the claim is filed, then drafts the fix, and it pairs that with an appeals and denials module so compliance and revenue integrity live in one place. At Sobrius Health, a multi-site Virginia SUD provider, pre-submission documentation accuracy moved from 73% to 96%. Adentris is HIPAA compliant and SOC 2 certified, with 42 CFR Part 2 controls and BAAs in place. To see it on your own charts, book a 30-minute call with our team.
The bottom line
If you want broad, at-scale clinical-quality auditing across behavioral health, mental health, and ABA, Brellium is a strong fit. If you run a SUD or behavioral health program and your pain is denied claims, ASAM and 42 CFR Part 2 gaps, and appeals, Adentris is built for that, catches and corrects the gap before submission, and runs on any EHR.
Related reading
- AI chart review tools for behavioral health
- Best behavioral health documentation compliance software
- Behavioral health payer audit readiness solutions
Frequently asked questions
What is the difference between Adentris and Brellium?
Both are AI chart-audit platforms for behavioral health. Adentris reviews notes in real time before the claim is submitted, drafts the correction, and is built around SUD-specific rules like ASAM level of care and 42 CFR Part 2, running on any EHR through a secure web agent. Brellium is an AI clinical compliance and chart auditing platform that reviews charts at scale across behavioral health, mental health, and ABA. The main differences are timing, SUD depth, and whether denials are handled in the same tool.
Can Adentris and Brellium be used together?
Yes. They solve different halves of the problem, so a program can use Brellium to audit charts at scale and Adentris to verify the documentation supports the claim and to handle appeals. Adentris reviews the note however it was written, so it fits alongside Brellium.
Is Adentris a good alternative to Brellium?
For programs whose problem is denials and audit exposure rather than broad clinical-quality auditing, yes. Adentris focuses on catching and correcting the behavioral health and SUD gaps that drive denials before submission, with ASAM and 42 CFR Part 2 built in and an appeals and denials module, and it runs on any EHR without a migration.
Which is better for a substance use disorder program?
For SUD, the claims that get denied usually turn on ASAM level of care, medical necessity, and 42 CFR Part 2, which Adentris is built around with real-time, pre-submission review and drafted corrections. Brellium is strong for broad clinical-quality auditing across behavioral health and ABA. Programs that want SUD-specific compliance depth and denials support often lean Adentris.
About the author: Sergey Yudovskiy is the Chief Product Officer of Adentris, which builds AI for revenue integrity and documentation compliance in behavioral health and substance use disorder care.